PPIs may not work if you have non-acid reflux, improper dosing timing, or an underlying condition like H. pylori infection. Some people also develop tolerance over time.
You should consider stopping PPIs when symptoms improve (typically after 2-4 weeks), if you experience significant side effects, or if your doctor recommends tapering off them.
Long-term PPI use may affect nutrient absorption (like magnesium and B12), alter gut microbiome, and potentially increase risk of certain infections and bone fractures.