4043 has higher silicon content (5%) which improves fluidity and crack resistance, while 5356 contains magnesium (5%) for higher strength and better color matching after anodizing.
Use 4043 for welding 3003, 3004, 5052, 6061, and 6063 aluminum alloys, especially when working with thin materials or needing superior crack resistance.
5356 provides higher tensile strength (up to 38,000 psi vs 30,000 psi for 4043), better ductility, and maintains its color better when anodized, making it ideal for structural applications.